header image

Flynn Lab



Principal Investigator

JoAnne L. Flynn, PhD
View profile

Location

5065 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15260

Research Description

Bone-marrow derived macrophages display heterogeneous phenotypesMy primary interest is in the interaction of pathogens with the host, with special emphasis on the immune mechanisms that protect against or exacerbate disease. Our focus is on Mycobacterium tuberculosis, the organism responsible for tuberculosis, which causes 2 million deaths per year worldwide. We are investigating the immune responses required for protection against tuberculosis, and the effect of these immune responses on both the host and the bacterium. We specifically study cytokine production, macrophage activation, and T cell subsets (CD4+ and CD8+ T cells) that are important in tuberculosis.

CD20... T cell- and B cell-mediated adaptive responses originate from cell-cell interactions that are initiated in lymph nodesFinally, we have a strong interest in the immune mechanisms responsible for maintaining a latent M. tuberculosis infection, and how deficiencies in the immune response can result in reactivation of disease. Our work is done in two model systems: mice and non-human primates. We have vaccine studies, drugs studies, and basic immunologic and pathogenesis studies ongoing. We also participate in projects involving mathematical modeling of the immune response to M. tuberculosis, and our plan is to incorporate nuclear imaging of live animals into our research.

Lab Members

 Daniel Fillmore, Research Technician Joshua Mattila, Research Instructor
Amy Fraser, Lab Manager Melanie O'Malley, Senior Research Specialist
Hannah Gideon, Postdoctoral Associate Jaime Tomko, Senior Research Specialist
Paul Johnston, Senior Research Specialist  
Pauline Maiello, Data AnalystTheresa Coleman, Data Analyst
Lonnie Frye, Medical Imaging Technician 

Members

Carolyn Mooney Bigbee -Senior Research Specialist
Catherine Thomas Cochran -Senior Research Specialist
Charles A. Scanga -Research Assistant Professor
Chelsea Chedrick -Research Specialist
Eileen Wong -Graduate Student
Mark A. Rodgers -Senior Research Specialist
Robert M. DiFazio -Graduate Student