Jianzhong Zhu, PhD

Research Associate


Dr. Jianzhong Zhu

Contact

412-623-7729
Fax: 412-623-7715

1.8 Hillman Cancer Center

5117 Center Avenue

Pittsburgh, PA 15213

Education

PhD in Preventive Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, 2000

MS in Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, 1997

BS in Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, 1994

Research Summary

I received my post-doctoral training in innate immune signaling in the context of infection, specifically focusing on the TLR cell signaling in macrophages which contributes to malaria pathogenesis, as well as the signaling mechanisms of mammalian TLRs.  I have continued similar line of research in Dr. Sarkar’s laboratory focusing in innate immune signaling and modulation during both virus infection and tumorigenesis of several cancer types. My work in this field has generated more than 10 first-author papers published in major journals. My expertise and knowledge in this field will contribute to the understanding of the critical components of a number of signaling pathways involved in anti-virus response by host and tumor progression, and the identification of the potential targets for prevention and/or therapy of either infection or tumors.

Research Lab Affiliation

Why I Chose Pitt

Pitt is a well known institute for bio-medical research; the city of Pittsburgh is also very good for living.

Publications

Kohanbash, G; Ishikawa, E; Fujita, M; Ikeura, M; McKaveney, K; Zhu, J; Sakaki, M; Sarkar, S. N; and Okada, H. (2012) Differential activity of interferon-α8 promoter is regulated by Oct-1 and a SNP that dictates prognosis of glioma. OncoImmunology. 1: 487-492. |  View Abstract

Zhu, J; Weinberg, R; Wu, X; Gowda, N. M; Muta, T; and Gowda, D. C. (2012) Ikappab-zeta plays an important role in the ERK-dependent dysregulation of malaria parasite GPI-induced IL-12 expression. IUBMB Life. 64: 187-193. |  View Abstract

Umemura, N; Zhu, J; Mburu, Y. K; Forero, A; Hsieh, P. N; Muthuswamy, R; Kalinski, P; Ferris, R. L; and Sarkar, S. N. (2012) Defective NF-kappaB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by double-stranded RNA. Cancer Res. 72: 45-55. |  View Abstract

Zhu, J; Krishnegowda, G; Li, G; and Gowda, D. C. (2011) Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1. Exp Parasitol. 128: 205-211. |  View Abstract

Zhu, J; Coyne, C. B; and Sarkar, S. N. (2011) PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. EMBO J. 30: 4838-4849. |  View Abstract

Mukherjee, A; Morosky, S. A; Shen, L; Weber, C. R; Turner, J. R; Kim, K. S; Wang, T; and Coyne, C. B. (2009) Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. J Biol Chem. 284: 6486-6494. |  View Abstract

Zhu, J; Smith, K; Hsieh, P. N; Mburu, Y. K; Chattopadhyay, S; Sen, G. C; and Sarkar, S. N. (2010) High-Throughput Screening for TLR3-IFN Regulatory Factor 3 Signaling Pathway Modulators Identifies Several Antipsychotic Drugs as TLR Inhibitors. J Immunol. 184: 5768-5776. |  View Abstract