Sidney M. Morris Jr., PhD

Professor Emeritus


Dr. Sid Morris

Contact

412-648-9338
Fax: 412-624-1401

516 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219-3143

Education

PhD in Biochemistry, University of California, Berkeley

Research Summary

Our research is directed toward elucidating the roles and regulation of the arginases in diseases such as asthma, sickle cell disease, hypertension, atherosclerosis, and diabetic nephropathy. As part of studies to determine the mechanism of action of the arginases in these diseases, we are investigating the signal transduction pathways, DNA elements and transcription factors involved in regulating expression of the arginase genes in response to cytokines and other agents that play key roles in the disease processes. Our long-term goal is to identify new targets for therapeutic intervention in disease.

Publications

Sheldon, KE; Shandilya, H; Kepka-Lenhart, D; Poljakovic, M; Ghosh, A. and Morris, S.M., Jr. (2013) Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter. J Immunol. [Epub date 08/02/2013] |  View Abstract

You, H; Gao, T; Cooper, T. K; Morris, S. M., Jr. and Awad, A. S. (2013) Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism. Kidney Int. [Epub date 06/14/2013] |  View Abstract

Mattila, J. T; Ojo, O. O; Kepka-Lenhart, D; Marino, S; Kim, J. H; Eum, S. Y; Via, L. E; Barry, C. E., 3rd; Klein, E; Kirschner, D. E; Morris, S. M., Jr.; Lin, P. L. and Flynn, J. L. (2013) Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms. J Immunol. 191: 773-784. |  View Abstract

Morris, S. M., Jr. (2012) Arginases and arginine deficiency syndromes. Curr Opin Clin Nutr Metab Care. 15: 64-70. |  View Abstract

Morris, S. M., Jr; Gao, T; Cooper, T. K; Kepka-Lenhart, D; and Awad, A. S. (2011) Arginase-2 mediates diabetic renal injury. Diabetes. 60: 3015-3022. |  View Abstract

Sharda, D. R; Yu, S; Ray, M; Squadrito, M. L; De Palma, M; Wynn, T. A; Morris, S. M., Jr; and Hankey, P. A. (2011) Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase. J. Immunol 187: 2181-2192. |  View Abstract

Morris, S. M., Jr. (2009) Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol. 157: 922-930. |  View Abstract