Jennifer Bomberger, PhD

Assistant Professor


Dr. Bomberger

Contact

412-624-1963
Fax: 412-624-1401

416 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219-3143

Education

PhD in Cellular and Molecular Physiology, Michigan State University

Research Summary

Dr. Bomberger’s research program is focused on understanding host-pathogen interactions, and more specifically, how each influences the other during an infection. Emerging evidence reveals that pathogens have the ability to modulate the host response to infection, while at the same time, respond to host defense by altering their virulence and antibiotic resistance. However, there is little understanding of the determinants of bacterial virulence, and how the host environment can modify this virulence. Dr. Bomberger’s research focuses on the interaction of an opportunistic pathogen, Pseudomonas aeruginosa, with the host airway epithelium as a model system to investigate the broader question of how the host impacts a pathogen in the context of an infection, and vice versa. In addition, Dr. Bomberger is also interested in understanding the mechanisms for viral-bacterial synergy in the lungs of chronic lung disease patients.

Research Lab Affiliation

Publications

Bomberger, J. M; Ye, S; Maceachran, D. P; Koeppen, K; Barnaby, R. L; O'Toole, G. A; and Stanton, B. A. (2011) A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system. PLoS Pathog. 7: e1001325. |  View Abstract

Bomberger, J. M; Guggino, W. B; and Stanton, B. A. (2011) Methods to monitor cell surface expression and endocytic trafficking of CFTR in polarized epithelial cells. Methods Mol Biol. 741: 271-283. |  View Abstract

Regulation of GPCR trafficking by ramps. Receptor Activity Modifying Proteins (RAMPs). Landes Bioscience. From the book RAMPs. Publication date: November 15, 2011 |  

Guo, Y; Dolinko, A. V; Chinyengetere, F; Stanton, B; Bomberger, J. M; Demidenko, E; Zhou, D. C; Gallagher, R; Ma, T; Galimberti, F; Liu, X; Sekula, D; Freemantle, S; and Dmitrovsky, E. (2010) Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARalpha and inhibits the growth of acute promyelocytic leukemia. Cancer Res. 70: 9875-9885. |  View Abstract

Bomberger, J. M; Barnaby, R. L; and Stanton, B. A. (2010) The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells. Channels (Austin). 4: 150-154. |  View Abstract

Bahl, C. D; Morisseau, C; Bomberger, J. M; Stanton, B. A; Hammock, B. D; O'Toole, G. A; and Madden, D. R. (2010) Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 192: 1785-1795. |  View Abstract

Bomberger, J. M; Maceachran, D. P; Coutermarsh, B. A; Ye, S; O'Toole, G. A; and Stanton, B. A. (2009) Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. PLoS Pathog. 5: e1000382. |  View Abstract