Jennifer Bomberger, PhD

Assistant Professor


Dr. Jennifer Bomberger

Contact

412-624-1963
Fax: 412-624-1401

416 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219-3143

Education

PhD in Cellular and Molecular Physiology, Michigan State University

Research Summary

Dr. Bomberger’s research program examines mechanisms for microbial pathogenesis and the interaction between bacterial and viral pathogens in the lung, particularly in the pathogenesis of chronic lung diseases like CF and chronic obstructive pulmonary disease (COPD). Many clinical studies show a strong correlation for respiratory virus infection with the acquisition of chronic P. aeruginosa infection in CF and COPD patients. Dr. Bomberger’s laboratory studies mechanisms for virus-stimulated P. aeruginosa biofilm formation with the goal of identifying potentially therapies to disrupt and/or prevent the P. aeruginosa biofilm formation that is so devastating to CF and COPD patients’ disease progression. Bacteria and viruses are exceptionally adept at exploiting host pathways to ensure their survival, and understanding this interplay is critical to combating diseases associated with microbial infection. 

Research Lab Affiliation

Publications

Zemke AC, Kocak BR and Bomberger JM. (2016) Sodium nitrite inhibits killing of Pseudomonas aeruginosa biofilms by ciprofloxacin. Antimicrob Agents Chemother. [Epub ahead of print] |  View Abstract

Melvin JA and Bomberger JM. (2016) Compromised Defenses: Exploitation of Epithelial Responses During Viral-Bacterial Co-Infection of the Respiratory Tract. PLoS Pathog. 12: e1005797. |  View Abstract

Lashua LP, Melvin JA, Deslouches B, Pilewski JM, Montelaro RC and Bomberger JM. (2016) Engineered cationic antimicrobial peptide (eCAP) prevents Pseudomonas aeruginosa biofilm growth on airway epithelial cells. J Antimicrob Chemother. 71: 2200-2207. |  View Abstract

Hendricks MR, Lashua LP, Fischer DK, Flitter BA, Eichinger KM, Durbin JE, Sarkar SN, Coyne CB, Empey KM and Bomberger JM. (2016) Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity. Proc Natl Acad Sci USA. 113: 1642-1647. |  View Abstract

Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR and Bomberger JM. (2016) Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci USA. [Epub ahead of print] |  View Abstract

Deschamps JD, Ogunsola AF, Jameson JB, 2nd, Yasgar A, Flitter BA, Freedman CJ, Melvin JA, Nguyen JV, Maloney DJ, Jadhav A, Simeonov A, Bomberger JM and Holman TR. (2016) Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry. 55: 3329-3340. |  View Abstract

Zemke AC, Shiva S, Burns JL, Moskowitz SM, Pilewski JM, Gladwin MT and Bomberger JM. (2014) Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells. Free Radic Biol Med. 77: 307-316. |  View Abstract