DNA Replication and Repair

This research area focuses on the molecular mechanisms of DNA replication in microorganisms as well as the repair responses of mammalian cells following exposure to DNA damaging agents. Specific projects include mechanisms of rolling-circle replication of antibiotic resistance plasmids in bacteria, the role of protein kinases in DNA damage signal transduction, and relationship of DNA repair to cancer and aging.

Bernstein Lab 

Repair of DNA damage is crucial to prevent accumulation of mutations that can cause human disease, such as cancer. Our lab studies how double-strand breaks in the DNA, one of the most lethal types of DNA lesions, are repaired. Learn more>

Cooper Lab

The primary goal of our laboratory is to understand how bacterial populations evolve and adapt to colonize hosts and cause disease. We are particularly focused on how bacterial populations form complex communities within biofilms and how cells perceive cues to attach or disperse. Learn more>

Khan Lab 

We are involved in three main areas of research. The first one deals with the role of microRNAs in human papillomavirus-associated cervical and oral cancers as well as role of miRNAs in aging. The second area deals with the cellular functions and mechanism of action of the PcrA helicase which is specifically found in Gram-positive bacteria. The third area of our interest deals with a molecular analysis of the role of the RepX protein in the replication and segregation of the anthrax toxin-encoding pXO1 plasmid in Bacillus anthracis. Learn more>

Levine Lab

To preserve the integrity of the genome, cells have developed various sophisticated mechanisms for repairing damaged DNA. The major DNA repair process that removes helixdistorting lesions from DNA, including UV-induced cyclobutane pyrimidine dimers (CPD) and 6,4 PhotoProducts (6,4-PP) is the nucleotide excision repair (NER) pathway. However, in eukaryotic cells, NER operates on chromatin-embedded DNA substrates and DNA folding with histone proteins into chromatin poses structural constraints likely to challenge detection and repair of DNA lesions. Only recently there has been an emphasis on the relationship of chromatin to NER. Learn more>

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Microbial Pathogenesis

Basic insights regarding the mechanisms of the host-pathogen relationship are essential to improvements in infectious disease prevention, vaccine development, and antimicrobial drug design. MMG faculty members are investigating the molecular biology and host immune responses to a diverse group of human pathogens responsible for tuberculosis, AIDS, yellow fever, dengue fever, tularemia, and Clostridia-associated food poisoning.

Apetrei Lab 

My laboratory is interested in the study of the HIV/ SIV diversity and pathogenesis. The AIDS pandemic is produced by two different viruses, HIV-1 and HIV-2. These two viruses resulted from cross-species transmissions of SIVs, the viruses that naturally infect nonhuman primate species (NHPs) in Africa.  Learn more>

Bina Lab 

Our research is centered on defining the molecular mechanisms used by bacteria to resist antibiotics and cause disease in humans. Our work currently focuses on two important gram negative human pathogens: Vibrio cholerae and Francisella tularensisLearn more>

Bomberger Lab

My research program is focused on understanding host-pathogen interactions, and more specifically, how each influences the other during an infection.  Emerging evidence reveals that pathogens have the ability to modulate the host response to infection, while at the same time, respond to host defense by altering their virulence and antibiotic resistance. Learn more>

Cooper Lab

The primary goal of our laboratory is to understand how bacterial populations evolve and adapt to colonize hosts and cause disease. We are particularly focused on how bacterial populations form complex communities within biofilms and how cells perceive cues to attach or disperse. Learn more>

Flynn Lab

My primary interest is in the interaction of pathogens with the host, with special emphasis on the immune mechanisms that protect against or exacerbate disease. Our focus is on Mycobacterium tuberculosis, the organism responsible for tuberculosis, which causes 2 million deaths per year worldwide. Learn more>

Klimstra Lab 

The goal has been to define the host and viral factors that determine the success or failure of the innate immune response to infection with arthropod-borne viruses. Learn more>

Lakdawala Lab

Our lab studies the molecular properties contributing to the epidemiological success of influenza A viruses to better predict future pandemics. There are two main areas of research in my lab 1) exploring the intracellular dynamics of influenza viral RNA assembly and 2) defining the viral properties necessary for efficient airborne transmission of influenza viruses. Learn more>

McClane Lab

Our research is focused on understanding bacterial pathogenesis, which remains a major medical problem in both developing and developed countries. Learn more>

Richardson Lab

The Richardson Lab is primarily focused on the effects of immunometabolism on infectious disease outcomes. Specifically, we study immunometabolism in the context of infections caused by the Gram-positive pathogen Staphylococcus aureus. Learn more>

Thomas Lab

Our research program focuses on signaling pathways that integrate membrane traffic with the regulation of homeostasis and the onset of disease. These studies were grounded by our identification of the proprotein convertase furin, which is the first member of a family of secretory pathway-localized endoproteases that catalyze the activation of bioactive proteins and peptide hormones. Learn more>

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Gene Regulation and Signal Transduction

Researchers in this area are focused on signaling and transcriptional responses of cells to their environment and to microbial pathogens. Project examples include glucose-induced kinase responses in yeast, transcriptional responses of macrophages to cytokines and inflammation, Toll-like receptors and the innate immune response, and regulation of herpesvirus gene expresion.

DeLuca Lab 

Repression and activation of persisting HSV genomes: Herpes simplex virus can undergo either a productive infection, where all the viral genes are expressed culminating in the production of progeny virus and cell death, or it can enter a latent state, which is characterized by the relative lack of viral gene expression, genome persistence, and cell survival. Learn more>

Lee Lab

Our lab is studying the RNA-RNA based recruitment mechanism utilized in EBV in greater detail with the goal to extrapolate our findings to the host cell. Since viruses often adopt existing mechanisms from their hosts, our observation suggests that cellular ncRNAs might exist that use RNA-RNA interactions to guide transcription factors to their target sites. Learn more>

Khan Lab

We are involved in three main areas of research. The first one deals with the role of microRNAs in human papillomavirus-associated cervical and oral cancers as well as role of miRNAs in aging. The second area deals with the cellular functions and mechanism of action of the PcrA helicase which is specifically found in Gram-positive bacteria. The third area of our interest deals with a molecular analysis of the role of the RepX protein in the replication and segregation of the anthrax toxin-encoding pXO1 plasmid in Bacillus anthracis. Learn more>

Sarkar Lab

Innate immunity of an organism is the inborn protection against invading pathogens. Because it is inborn, and entrusted with the protection of host from a vast array of previously unknown invaders, the innate immune system generates a generalized alert response upon pathogen detection. This alert is chemically mediated by a class of molecules called Cytokines. Learn more>

Schmidt Lab

My lab studies the Snf1 kinase of yeast. The mammalian homologue of Snf1 is the AMP-activated protein kinase, an important therapeutic target for type II diabetes. Biochemical and genetic experiments have shown that Snf1 kinase is regulated by phosphorylation of the conserved threonine residue in the kinase activation loop. Learn more>

Xiao-Qu Lab

Our primary research interests include the study of signaling transduction pathways in immunity and tumorigenesis, particularly NF-kB, as well as the molecular mechanisms underlying the type-1 human T cell leukemia virus (HTLV-I) mediated T cell transformation for disease prevention and therapeutic purposes. Learn more>

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Molecular Virology

Understanding the molecular basis of viral interactions with their hosts requires a more complete picture of virus structure and regulation at the molecular level. Groups in this focus area are investigating the regulation of viral gene expression, mechanisms of viral capsid assembly and DNA packaging, alterations in host cell signaling by HIV accessory factors, virus entry into host cells, as well as engineering viral vectors for the analysis of host cell function.

DeLuca Lab

Repression and activation of persisting HSV genomes: Herpes simplex virus can undergo either a productive infection, where all the viral genes are expressed culminating in the production of progeny virus and cell death, or it can enter a latent state, which is characterized by the relative lack of viral gene expression, genome persistence, and cell survival. Learn more>

Glorioso Lab

Dr. Glorioso’s most recent research has focused on (i) the design and application of HSV gene vectors for exploring the molecular events that occur in sensory afferents that are involved in the transition from acute to chronic pain. Learn more>

Homa Lab

Research in our lab is focused on understanding the mechanism of herpesvirus capsid assembly and DNA packaging.  Learn more>

Lakdawala Lab

Our lab studies the molecular properties contributing to the epidemiological success of influenza A viruses to better predict future pandemics. There are two main areas of research in my lab 1) exploring the intracellular dynamics of influenza viral RNA assembly and 2) defining the viral properties necessary for efficient airborne transmission of influenza viruses. Learn more>

Shair Lab

The Shair lab studies the molecular mechanisms of cancer induced by this latent virus with the purpose of defining how these mechanisms contribute to the oncogenic and metastatic properties of EBV-associated diseases. Learn more>

Xiao-Qu Lab

Our primary research interests include the study of signaling transduction pathways in immunity and tumorigenesis, particularly NF-kB, as well as the molecular mechanisms underlying the type-1 human T cell leukemia virus (HTLV-I) mediated T cell transformation for disease prevention and therapeutic purposes. Learn more>

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Faculty

Our faculty provide outstanding mentoring to enable students and postdoctoral fellows learn how to identify and tackle critical biomedical research problems.

Alumni

After graduation, our graduate students move on to various careers. Some have opted for Academia, either at research or teaching Universities, while others have ventured into the growing biotechnology sector. Here is a listing of our recent graduates.

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