Carolyn Coyne, PhD

Associate Professor


Dr. Coyne

Contact

412-383-5149
Fax: 412-624-1401

427 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219-3143

Education

PhD in Pharmacology, University of North Carolina at Chapel Hill

Research Summary

The research in my lab combines important aspects of virology, immunology, and cell biology to dissect various aspects of host-virus interactions, with a particular focus on polarized cell types. In particular, we focus on—(1) on the mechanisms by which enteroviruses have evolved to successfully circumnavigate the barriers presented by polarized cells to facilitate virus entry, replication, and spread, (2) on the mechanisms utilized by enteroviruses to evade and/or suppress innate immune signaling,  (3) on the identification of novel regulators and components of the innate immune system, and (4) on the role of placental-specific microRNAs in antiviral signaling and the induction of autophagy at the maternal-fetal interface.

Research Lab Affiliation

Areas of Interest

Host-pathogen interactions; Innate Immune Signaling

Publications

Delorme-Axford, E; Sadovsky, Y; Coyne, C. B. (2013) Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. J Virol. 87: 8569-8581. |  View Abstract

Delorme-Axford, E; Donker, R. B; Mouillet, J. F; Chu, T; Bayer, A; Ouyang, Y; Wang, T; Stolz, D. B; Sarkar, S. N; Morelli, A. E; Sadovsky, Y and Coyne, C. B. (2013) Human placental trophoblasts confer viral resistance to recipient cells. Proc Natl Acad Sci USA. 110: 12048-12053. |  View Abstract

Bozym, R. A; Delorme-Axford, E; Harris, K; Morosky, S; Ikizler, M; Dermody, T. S; Sarkar, S. N and Coyne, C. B. (2012) Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling. Cell Host Microbe. 11: 153-166. |  View Abstract

Mukherjee, A; Morosky, S. A; Delorme-Axford, E; Dybdahl-Sissoko, N; Oberste, M. S; Wang, T and Coyne, C. B. (2011) The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. PLoS Pathog. 7: e1001311. |  View Abstract

Coyne, C. B; Bozym, R; Morosky, S. A; Hanna, S. L; Mukherjee, A; Tudor, M; Kim, K. S; and Cherry, S. (2011) Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers. Cell Host Microbe. 9: 70-82. |  View Abstract

Bozym, R. A; Patel, K; White, C; Cheung, K. H; Bergelson, J. M; Morosky, S. A; and Coyne, C. B. (2011) Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. Mol Biol Cell. 22: 3010-3021. |  View Abstract

Bozym, R. A; Morosky, S. A; Kim, K. S; Cherry, S; and Coyne, C. B. (2010) Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. PLoS Pathog. 6: e1001135. |  View Abstract