JoAnne L. Flynn, PhD

Distinguished Professor


Dr. Flynn

Contact

412-624-7743
Fax: 412-648-3394

5058 Biomedical Science Tower 3

3501 Fifth Avenue

Pittsburgh, PA 15260

Education

PhD in Microbial Genetics/Pathogenic Mechanisms, University of California, Berkeley

Research Summary

Dr. Flynn studies tuberculosis, a bacterial disease that kills 1.5 million people every year worldwide. Her areas of research include on host-pathogen interactions, immunology of Mycobacterium tuberculosis infection, HIV/TB coinfections, vaccines and immune interventions and anti-TB drugs. Dr. Flynn developed and uses non-human primate models for her tuberculosis research with cutting edge tools and technologies, including tissue based analyses and PET CT imaging.

Research Lab Affiliation

Publications

Myers, A. M; Marino, S; Kirschner, D. E and Flynn, J. L. Inoculation dose of Mycobacterium tuberculosis does not influence priming of T cell responses in lymph nodes. J. Immunol. [In press] 2013. |  

Green, A. M; Difazio, R and Flynn, J. L. IFN-gamma from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection. J Immunol. 190: 270-277. |  View Abstract

Via, L. E; Schimel, D; Weiner, D. M; Dartois, V; Dayao, E; Cai, Y; Yoon, Y. S; Dreher, M. R; Kastenmayer, R. J; Laymon, C. M; Carny, J. E; Flynn, J. L; Herscovitch, P and Barry, C. E., 3rd. Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [(1)(8)F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography. Antimicrob Agents Chemother. 56: 4391-4402. |  View Abstract

Phuah, J. Y; Mattila, J. T; Lin, P. L and Flynn, J. L. Activated B cells in the granulomas of nonhuman primates infected with Mycobacterium tuberculosis. Am J Pathol. 181: 508-514. |  View Abstract

Lin, P. L; Rutledge, T; Green, A. M; Bigbee, M; Fuhrman, C; Klein, E and Flynn, J. L. CD4 T Cell Depletion Exacerbates Acute Mycobacterium tuberculosis While Reactivation of Latent Infection Is Dependent on Severity of Tissue Depletion in Cynomolgus Macaques. AIDS Res Hum Retroviruses. [Epub ahead of print] |  View Abstract

Lin, P. L; Dartois, V; Johnston, P. J; Janssen, C; Via, L; Goodwin, M. B; Klein, E; Barry, C. E., 3rd and Flynn, J. L. Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. Proc Natl Acad Sci USA. 109: 14188-14193. |  View Abstract

Fallahi-Sichani, M; Flynn, J. L; Linderman, J. J and Kirschner, D. E. Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability. J Immunol. 188: 3169-3178. |  View Abstract