JoAnne L. Flynn, PhD

Distinguished Professor

Dr. JoAnne Flynn



5058 Biomedical Science Tower 3

3501 Fifth Avenue

Pittsburgh, PA 15260


Postdoc, Albert Einstein College of Medicine

Postdoc, Research Institute of Scripps Clinic

PhD in Microbial Genetics/Pathogenic Mechanisms, University of California, Berkeley

BS in Biochemistry, University of California, Davis

Research Summary

Our lab focuses on tuberculosis. We study host-pathogen interactions, immunology of tuberculosis, vaccines and drugs. We developed and use non-human primate models of tuberculosis for all our work. We also study HIV/M. tuberculosis co-infections in non-human primate models.

Click here for a full listing of publications

Research Lab Affiliation


Gideon HP*, Hughes TK*, Tzouanas CN*, Wadsworth MH, Tu AA, Gierahn TM, Peters JM, Hopkins FF, Wei J-R, Kummerlowe C, Grant NL, Nargan K, Phuah JY, Borish HJ, Maiello P, White AG, Winchell CG, Nyquist SK, Ganchua SKC, Myers A, Patel KV, Ameel CL, Cochran CT, Ibrahim S, Tomko JA, Frye LJ, Rosenberg JM, Shih A, Chao M, Klein E, Scanga CA, Ordovas-Montanes J, Berger B, Mattila JT, Madansein R, Love JC, Lin PL, Leslie A, Behar SM, Bryson B, Flynn JL#, Fortune SM#, Shalek AK#. Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control. Immunity 2022 May 10;55(5):827-846.e10. doi: 10.1016/j.immuni.2022.04.004. Epub 2022 Apr 27. *co-first authors; # co-senior authors |  View Abstract

Grant NL, Maiello P, Klein E, Lin PL, Borish HJ, Tomko J, Frye LJ, White AG, Kirschner DE, Mattila JT, Flynn JL. T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cell Reports 39:7, p.110826, May 17, 2022. |  View Abstract

Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH, Hughes TK, Pokkali S, Swanson PA, Grant NL, Rodgers MA, Kamath M, Causgrove CM, Laddy DJ, Bonavia A, Casimiro D, Lin PL, Klein E, White AG, Scanga CA, Shalek AK, Roederer M*, Flynn JL*, Seder RA*. Prevention of tuberculosis in nonhuman primates following intravenous BCG immunization. Nature, 2020. Jan; 577(7788): 95-102. Epub 2020 Jan 1. |  View Abstract

Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. PLoS Pathog. 2018 Oct 12; 14(10):e1007305. doi: 10.1371/journal.ppat.1007305. eCollection 2018 Oct. |  View Abstract

Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL. Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques. PLoS Pathog. 2018 Nov 1;14(11):e1007337. doi: 10.1371/journal.ppat.1007337. eCollection 2018 Nov. |  View Abstract