Kathy H.Y. Shair, PhD

Assistant Professor


Dr. Kathy H.Y. Shair

Contact

412-623-7717
Fax: 412-623-7715

1.8 Hillman Cancer Center

5117 Centre Avenue

Pittsburgh, PA 15213

Education

PhD in Virology, University of Cambridge (U.K.)

Research Summary

Cancer is a complex disease with multiple etiologies including host, environmental and microbial factors.  It is estimated that more than 15% of all human cancers are associated with a viral infection.  My laboratory studies the oncogenic mechanisms of the -herpesvirus Epstein-Barr virus (EBV) in epithelial and lymphoid malignances.  EBV is the first discovered human tumor virus.  Human infection is ubiquitous with nearly 200,000 EBV-associated new cancer cases per year worldwide.  These include immuno-competent (nasopharyngeal carcinoma, gastric carcinoma, Hodgkin lymphoma, Burkitt lymphoma) and immuno-suppressed (post-transplant and AIDs-associated lymphomas) cancers.  In the absence of a prophylactic vaccine, more than 95% of adults by 35-40 years of age are persistently infected.  The Shair lab studies how virus-host interactions alter the infection outcome and biology of the infected cell, and how viral modulation of DNA repair mechanisms could be a risk-factor.  Using cell-based and polarized 3D epithelial culture models, we use molecular virology to elucidate the oncogenic mechanisms of nasopharyngeal carcinoma.  We also utilize mouse models and clinical specimens to determine biological significance, as well as for the discovery of cancer biomarkers.  By studying 1) EBV oncogenic mechanisms, 2) determinants of EBV pathogenesis and 3) biomarkers, we can begin to understand the molecular determinants of virus-associated cancers and ultimately guide us in developing effective therapeutic strategies.

Click here for a full listing of publications

Research Lab Affiliation

Publications

Caves EA, Butch RM, Cook SA, Wasil LR, Chen C, Di YP, Lee N, Shair KHY. 2017. Latent membrane protein 1 is a novel determinant of Epstein-Barr virus genome persistence and reactivation. mSphere 2: e00453-17. |  View Abstract

Goswami R, Shair KYH and Gershburg E. 2017. Molecular diversity of IgG responses to Epstein-Barr virus proteins in asymptomatic Epstein-Barr virus carriers. J Gen Virol: 98: 2343-2350. |  View Abstract

Wasil LR and Shair KH. 2015. Epstein-Barr virus LMP1 induces focal adhesions and epithelial cell migration through effects on integrin-alpha5 and N-cadherin. Oncogenesis. 4: e171. |  View Abstract

Wasil LR, Wei L, Chang C, Lan L and Shair KH. 2015. Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells. 89: 7612-7624. |  View Abstract

Shair KH, Bendt KM, Edwards RH, Nielsen JN, Moore DT and Raab-Traub N. 2012. Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model. J Virol. 86: 5352-5365. |  View Abstract