Laurel Thomas

Lab Manager

Laurel Thomas



534 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219


BSc in Biology, Boise State University

Research Summary

I am involved in several projects, including the mechanism by which HIV-1 Nef downregulates MHC-I molecules and the mechanism of TRAIL-induced apoptosis and the regulation of SIRT1 by PACS-2 in Diet induced Obesity.

Research Lab Affiliation

Why I Chose Pitt

The research opportunities and collaborations at the University of Pittsburgh are outstanding. As a transplant from the west coast, I find Pittsburgh charming with numerous cultural activities and beautiful parks and gardens.


Atkins, K. M; Thomas, L. L; Barroso, J.; Thomas, L.; Auclair, S.; Yin, J.; Kang, H.; Chung, J. H; Dikeakos, J. D; and Thomas G. (2014) The multi-functional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell cycle arrest. Cell Rep. 8: 1545-1557. |  View Abstract

Dikeakos, J. D; Thomas, L; Kwon, G; Elferich, J; Shinde, U; and Thomas, G. (2012) An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Mol Biol Cell. 23: 2184-2197. |  View Abstract

Dikeakos, J. D; Atkins, K. M; Thomas, L; Emert-Sedlak, L; Byeon, I. J; Jung, J; Ahn, J; Wortman, M. D; Kukull, B; Saito, M; Koizumi, H; Williamson, D. M; Hiyoshi, M; Barklis, E; Takiguchi, M; Suzu, S; Gronenborn, A. M; Smithgall, T. E; and Thomas, G. (2010) Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell. 21: 3279-3292. |  View Abstract

Aslan, J. E; You, H; Williamson, D. M; Endig, J; Youker, R. T; Thomas, L; Shu, H; Du, Y; Milewski, R. L; Brush, M. H; Possemato, A; Sprott, K; Fu, H; Greis, K. D; Runckel, D. N; Vogel, A; and Thomas, G. (2009) Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell. 34: 497-509. |  View Abstract

Atkins, K. M; Thomas, L; Youker, R. T; Harriff, M. J; Pissani, F; You, H; and Thomas, G. (2008) HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. J Biol Chem. 283: 11772-11784. |  View Abstract

Hung, C. H; Thomas, L; Ruby, C. E; Atkins, K. M; Morris, N. P; Knight, Z. A; Scholz, I; Barklis, E; Weinberg, A. D; Shokat, K. M; and Thomas, G. (2007) HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe. 1: 121-133. |  View Abstract

Scott, G. K; Fei, H; Thomas, L; Medigeshi, G. R; and Thomas, G. (2006) A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. Embo J. 25: 4423-4435. |  View Abstract