Leizhen Wei, PhD

Research Assistant Professor




2.6 Hillman Cancer Center

5117 Centre Avenue

Pittsburgh, PA 15232


PhD in Medical Science, Tohoku University, Japan, 2008

PhD in Nature Science Genetics, China Medical University, China, 2006

Areas of Interest

1. Molecular mechanisms of cancer, especially due to genomic instability; DNA damage repair pathway; precise genetic cancer diagnosis and effectual treatment methods. 2. Familial carcinomas research; familial carcinomas genetic counseling.

Why I Chose Pitt

Similar research interest.


Xing, M; Yang, M; Huo, W; Feng, F; Wei, L; Jiang, W; Ning, S; Yan, Z; Li, W; Wang, Q; Hou, M; Dong, C; Guo, R; Gao, G; Ji, J; Zha, S; Lan, L; Liang, H and Xu D. (2015) Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun. 6: 6233. |  View Abstract

Lee, H.J; Lan, L; Peng, G; Chang, W.C; Hsu, M.C; Wang, Y.N; Cheng, C.C; Wei, L; Nakajima, S; Chang, S.S; Liao, H.W; Chen, C.H; Lavin, M; Ang, K.K; Lin, S.Y. and Hung, M.C. (2015) Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res. 25: 225-236. |  View Abstract

Nakajima, S; Lan, L; Wei, L; Hsieh, L. C; Rapić-Otrin, V; Yasui, A and Levine, A. S. (2014) Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks. PLoS One. 9: e84899. |  View Abstract

Matsuzawa, A; Kanno, S; Nakayama, M; Mochiduki, H; Wei, L; Shimaoka, T; Furukawa, Y; Kato, K; Shibata, S; Yasui, A; Ishioka, C and Chiba, N. (2014) The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. Mol Cell. 53: 101-114. |  View Abstract

Lan, L; Nakajima, S; Wei, L; Sun, L; Hsieh, C.L; Sobol, R.W; Bruchez, M; Van Houten, B; Yasui, A and Levine, A.S. (2013) Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Nucleic Acids Res. 42: 2330-2345. |  View Abstract

Fang, Q; Inanc, B; Schamus, S; Wang, X.H; Wei, L; Brown, A.R; Svilar, D; Sugrue, K.F; Goellner, E.M; Zeng, X; Yates, N.A; Lan, L; Vens, C and Sobol R.W. (2014) HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase beta. Nat Commun. 5: 5513. |  View Abstract

Benitez, A; Yuan, F; Nakajima, S; Wei, L; Qian, L; Myers, R; Hu, J.J; Lan, L. and Zhang, Y. (2014) Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein. Nucleic Acids Res. 42: 1671-1683. |  View Abstract