Masahiro Shuda, PhD

Assistant Professor

Dr. Masa Shuda


Fax: 412-623-7715

1.9 Hillman Cancer Center

5117 Centre Avenue

Pittsburgh, PA 15213


PhD in Molecular Virology, Tokyo Medical and Dental University

BS in Health Science, Tokyo Medical and Dental University

Research Summary

Tumor virus research has provided a wealth of information for cancer biology. Polyomaviruses
in particular have been central to understanding basic mechanisms of cancer cell transformation. Studies on the SV40 T antigen, for example, led to the discovery of p53 and uncovered the functions of retinoblastoma tumor suppressor protein in cell cycle regulation. Research on murine polyomavirus led to the discovery of tyrosine phosphorylation and the phosphoinositide 3-kinase signaling pathway. Each new cancer virus provides a new model for investigating basic pathways in carcinogenesis. My research exploits the most recently discovered human tumor virus, Merkel cell polyomavirus (MCV), to identify novel cellular pathways leading to cancer.

Research Lab Affiliation


Guastafierro, A; Feng, H; Thant, M; Kirkwood, J. M; Chang, Y; Moore, P. S. and Shuda M. (2012) Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods. 187: 6-14. |  View Abstract

Arora, R; Shuda, M; Guastafierro, A; Feng, H; Toptan, T; Tolstov, Y; Normolle, D; Vollmer, L. L; Vogt, A; Domling, A; Brodsky, J. L; Chang Y. and Moore P. S. (2012) Survivin is a therapeutic target in Merkel cell carcinoma. Sci Transl Med. 133: 133ra56. |  View Abstract

Shuda, M; Kwun, H. J; Feng, H; Chang, Y; and Moore, P. S. (2011) Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest. 121: 3623-3634. |  View Abstract

Houben, R; Shuda, M; Weinkam, R; Schrama, D; Feng, H; Chang, Y; Moore, P. S. and Becker, J. C. (2010) Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol. 84: 7064-7072. |  View Abstract

Shuda, M; Arora, R; Kwun, H. J; Feng, H; Sarid, R; Fernandez-Figueras, M. T; Tolstov, Y; Gjoerup, O; Mansukhani, M. M; Swerdlow, S. H; Chaudhary, P. M; Kirkwood, J. M; Nalesnik, M. A; Kant, J. A; Weiss, L. M; Moore, P. S. and Chang, Y. (2009) Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int. J Cancer. 125: 1243-1249. |  View Abstract

Shuda, M; Feng, H; Kwun, H. J; Rosen, S. T; Gjoerup, O; Moore, P. S; and Chang, Y. (2008) T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA. 105: 16272-16277. |  View Abstract

Feng, H; Shuda, M; Chang, Y; and Moore, P. S. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 319: 1096-1100. |  View Abstract