Patrick S. Moore, MD, MPH

Distinguished Professor


Dr. Moore

Contact

412-623-7718
Fax: 412-623-7715

1.8C Hillman Cancer Center

5117 Centre Avenue

Pittsburgh, PA 15213-1862

Education

MD, University of Utah

MPH in Epidemiology, University of California, Berkeley

Research Summary

Our lab investigates viral causes of human malignancy and identifies new cancer-causing viruses using digital transcriptome subtraction. We currently focus on two agents we have discovered, KSHV (the viral cause of Kaposi’s sarcoma) and MCV (the viral cause for most Merkel cell carcinomas). We focus on the basic molecular virology of transformation as well as develop assays that have clinical value in detecting tumor virus infection. Most recently, we have characterized MCV mutations that truncate the MCV T antigen helicase to disable viral replication in tumors. We have also developed MCV T antigen monoclonal antibodies and virus-like particle serologic tests that allow us to screen patients and tissues for MCV infection. Additional research involves the search for potential KSHV vaccine candidates through analysis of latent KSHV protein immune processing.  

Research Lab Affiliation

Publications

Liu, X; Hein, J; Richardson, S. C; Basse, P. H; Toptan, T; Moore, P. S; Gjoerup, O. V; and Chang, Y. (2011) Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus. J Biol Chem. 286: 17079-17090. |  View Abstract

Shuda, M; Kwun, H. J; Feng, H; Chang, Y; and Moore, P. S. (2011) Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest. 121: 3623-3634. |  View Abstract

Shuda, M; Feng, H; Kwun, H. J; Rosen, S. T; Gjoerup, O; Moore, P. S; and Chang, Y. (2008) T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA. 105: 16272-16277. |  View Abstract

Feng, H; Shuda, M; Chang, Y; and Moore, P. S. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 319: 1096-1100. |  View Abstract

Russo, J. J; Bohenzky, R. A; Chien, M. C; Chen, J; Yan, M; Maddalena, D; Parry, J. P; Peruzzi, D; Edelman, I. S; Chang, Y; and Moore, P. S. (1996) Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA. 93: 14862-14867. |  View Abstract

Cesarman, E; Chang, Y; Moore, P. S; Said, J. W; and Knowles, D. M. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 332: 1186-1191. |  View Abstract

Chang, Y; Cesarman, E; Pessin, M. S; Lee, F; Culpepper, J; Knowles, D. M; and Moore, P. S. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 266: 1865-1869. |  View Abstract