Vaughn S Cooper, PhD
425 Bridgeside Point 2
450 Technology Drive
PhD in Zoology/Ecology and Evolutionary Biology, Michigan State University, 2000
AB magna cum laude, Biology, Amherst College, 1994
- To understand how bacteria adapt to new environments and/or cause disease. Biofilm-associated infections are our primary focus. We conduct high-throughput genomic analysis of evolved populations and longitudinal studies of infectious isolates. We also develop genome-based diagnostics for bacterial infections.
- To advance understanding of evolutionary dynamics in structured communities, relevant to biofilms, solid tumors, and the origins of multicellularity.
- To explore variation in genome evolutionary rates associated with replication timing and the cell cycle to improve genome legibility, understand speciation, and to guide more rational treatment of disease states.
- To propagate experimental evolution as a both a) a nuanced screen for gain-of-function mutations and b) a method of active learning by students of all ages
Research Lab Affiliation
Ellis C.N, Traverse C.C, Mayo-Smith L, Buskirk S.W. and Cooper V.S. (2015) Character displacement and the evolution of niche complementarity in a model biofilm community. Evolution. 69: 283-293. | View Abstract
Dillon M.M, Sung W, Lynch M. and Cooper V.S. (2015) The Rate and Molecular Spectrum of Spontaneous Mutations in the GC-Rich Multichromosome Genome of Burkholderia cenocepacia. Genetics. 200: 935-946. | View Abstract
Traverse C.C, Mayo-Smith L.M, Poltak S.R. and Cooper V.S. (2013) Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections. Proc Natl Acad Sci USA. 110: E250-9. | View Abstract
Flynn K.M, Cooper T.F, Moore F.B. and Cooper V.S. (2013) The environment affects epistatic interactions to alter the topology of an empirical fitness landscape. PLoS Genet. 9: e1003426. | View Abstract
Poltak S.R. and Cooper V.S. (2011) Ecological succession in long-term experimentally evolved biofilms produces synergistic communities. ISME J. 5: 369-378. | View Abstract
Cooper V.S, Vohr S.H, Wrocklage S.C. and Hatcher P.J. (2010) Why genes evolve faster on secondary chromosomes in bacteria. PLoS Comput Biol. 6: e1000732. | View Abstract
Cooper V.S. and Lenski R.E. (2000) The population genetics of ecological specialization in evolving Escherichia coli populations. Nature. 407: 736-739. | View Abstract