Jodi Kristine Craigo, Ph.D.


Jodi Craigo Research Assistant Professor
W1101 BSTWR
200 Lothrop Street
Pittsburgh, Pennsylvania 15261

Phone: (412) 648-8874
Fax: (412) 624-8897
E-mail: craigoj@pitt.edu

Biography


      Dr. Craigo has been a Research Assistant Professor in the Department of Molecular Genetics and Biochemistry at the University of Pittsburgh School of Medicine since 2006. She recently accepted the position of Senior Research Manager for the University of Pittsburgh's Center for Vaccine Research. Jodi received her Ph.D. in Cellular and Molecular Biology in 1997 from Northeastern Ohio Universities College of Medicine in Rootstown, Ohio. She came to Pittsburgh in January of 1998 as a Post-Doctoral Research Associate in the laboratory of Dr. Ronald Montelaro. Her research interest is in HIV-1 and animal lentivirus (EIAV) persistence, pathogenesis, and vaccine development.

Research


      My research into the characterization of lentiviral persistence and pathogenesis is conducted through evolutionary studies of both HIV and EIAV via sequence analysis. Our evolutionary analysis of lentiviral populations via quasispecies sequence analysis includes determinations of phenotypic differences of conserved and immunodominant regions of protein variation utilizing multiple computational avenues including: phylogenetics, divergence and selection analyses, and compartmentalization analyses (including Slatkin-Maddison, Mantel and GeneFlow computations). I also serve as the Project Manager for the Montelaro lab EIAV vaccine development grant (NIH) and our vaccine contract work with Intervet, Inc. Our lentiviral vaccine development is based in various modalities such as live attenuated, viral vector and virus like particle vaccines. Our vaccine research applies what we learn from pathogenesis studies into mechanisms of protection and results ultimately in the implementation of the new candidate vaccines into trials. In addition to the development of vaccine candidates we also focus on the creation of new, rigorous virus challenge models as well as detailed characterization of protective/non-protective immune system responses including BIAcore analysis of immune sera.

Selected Publications


  • Fidalgo-Carvalho I, Craigo JK, Barnes S, Costa-Ramos C, Montelaro RC. 2009 "Characterization of an equine macrophage cell line: Application to studies of EIAV infection" Vet Microbiol. 136:8-19. | Abstract


  • Tagmyer TL, Craigo JK, Cook SJ, Even DL, Issel CJ, Montelaro RC. 2008 "Envelope determinants of equine infectious anemia virus vaccine protection and the effects of sequence variation on immune recognition" J Virol. 82:4052-63. | Abstract


  • Craigo JK, Zhang B, Barnes S, Tagmyer TL, Cook SJ, Issel CJ, Montelaro RC. 2007. "Envelope variation as a primary determinant of lentiviral vaccine efficacy" Proc Natl Acad Sci USA 104:15105-10. | Abstract


  • Toapanta FR, Craigo JK, Montelaro RC, Ross TM. 2007. "Reduction of anti-HIV-1 Gag immune responses during co-immunization: immune interference by the HIV-1 envelope" Curr HIV Res. 5:199-209. | Abstract


  • Craigo JK, Durkin S, Sturgeon TJ, Tagmyer T, Cook SJ, Issel CJ, Montelaro RC. 2007. "Immune suppression of challenged vaccinates as a rigorous assessment of sterile protection by lentiviral vaccines" Vaccine 25:834-45. | Abstract


  • Craigo, J.K., Sturgeon, T., Cook, S., Issel, C., Leroux, C., and Montelaro, R.C. (2006) Apparent Elimination of Ancestral Quasispecies in EIAV Long-Term Inapparent Carriers. Virology 344: 340-353. | Abstract


  • Craigo, J.K. and Gupta, P. (2006) HIV-1 in Genital Compartments: Vexing Viral Reservoirs. Current Opinion in HIV and AIDS. 1:97-102. | Abstract


  • Craigo, J.K., Li, F., Howe, L., Steckbeck, J.D., Cook, S.J., Issel, C., and Montelaro, R.C. (2005) Discerning An Effective Balance Between Equine Infectious Anemia Virus Attenuation And Vaccine Efficacy. Journal of Virology. 79: 2666-2677. | Abstract


  • Craigo, J.K., Patterson, B., Paranipe, S.G., Ding, M., Kulka, K., Montelaro, R.C., Mellors, J., and Gupta,P. (2004) Persistent HIV type 1 infection in semen and blood compartments in patients after long-term potent antiretroviral therapy. AIDS Research and Human Retroviruses. 20:1196-1209. | Abstract


  • Paranipe, S.G., Craigo, J., Patterson, B., Ding, M.,Barroso, P., Harrison, L., Montelaro, R.C., and Gupta, P. (2002) Subcompartmentalization of HIV-1quasispecies between seminal cells and seminal plasma indicates their origin in distinct genital tissues. AIDS Research and Human Retroviruses. 18: 1271-1280. | Abstract

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