Dr. Evans is an Assistant Professor in the Dept. of Microbiology and Molecular Genetics. He received his PhD in Molecular Microbiology from Stony Brook University in 2002. He studied retrovirus entry and uncoating at The Salk Institute for Biological Studies. Dr. Evans went on to develop a program in West Nile virus at Fox Chase Cancer Center. His research focuses on the complex interactions between flaviviruses and the innate immune system.
Research
Our research focuses on understanding the complex interactions between flaviviruses and the host innate immune response. West Nile virus (WNV) and dengue virus (DENV) are closely related flaviviruses that actively target and inhibit the interferon (IFN) response. We utilize a variety of molecular techniques in tissue culture models to dissect the intracellular signaling pathways abrogated by these viruses. A particular interest of the lab is to determine the viral proteins responsible for inhibition of IFN signaling. We are also investigating the mechanism through which these viruses modify the biochemical composition of the signaling cascade. In addition, we are currently initiating projects to screen for small molecule inhibitors as well as vaccine candidates against these viruses.
Selected Publications
Evans JD, Seeger C. 2007. "Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling" J Virol. 81:11809-16. | Abstract
Evans JD, Seeger C. 2006. "Cardif: a protein central to innate immunity is inactivated by the HCV NS3 serine protease" Hepatology 43:615-7. | Abstract
Assistant Professor