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Patrick S. Moore, M.D., M.P.H.
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American Cancer Society Professor
1.8 HCCLB
5117 Centre Avenue
Pittsburgh, Pennsylvania 15213
Phone: (412) 623-7718
Fax: (412) 623-7715
E-mail: psm9@pitt.edu
Lab Phone: (412) 623-7721
Lab Website
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Biography
Moore is the director of the Molecular Virology Program at the University of Pittsburgh Cancer Institute and codirects a lab with Prof. Yuan Chang working on KSHV and new pathogen discovery.
He has an MD (Univ Utah, '85), MS (Biophysical Chemistry, Stanford '80), and MPH (UC Berkeley '90), with postgraduate training in the EIS program at CDC and Preventive Medicine boards (UCSF '91). Past interests include epidemic epidemiology and refugee epidemiology, but his current interests involve the molecular biology of KSHV and viral tumorigenesis. Together with Dr. Chang, he discovered the most recently-described human tumor virus, KSHV. This work has been recognized by the Robert Koch Prize, the GM Cancer Research Foundation Mott Prize and the Meyenberg Cancer Research Prize.
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Research
Our lab investigates viral causes of human malignancy and identifies new cancer-causing viruses using digital transcriptome subtraction. We currently focus on two agents we have discovered, KSHV (the viral cause of Kaposi’s sarcoma) and MCV (the viral cause for most Merkel cell carcinomas). We focus on the basic molecular virology of transformation as well as develop assays that have clinical value in detecting tumor virus infection. Most recently, we have characterized MCV mutations that truncate the MCV T antigen helicase to disable viral replication in tumors. We have also developed MCV T antigen monoclonal antibodies and virus-like particle serologic tests that allow us to screen patients and tissues for MCV infection. Additional research involves the search for potential KSHV vaccine candidates through analysis of latent KSHV protein immune processing.
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Selected Publications
- Shuda M, Arora R, Kwun HJ, et al. 2009. "Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors" Int J Cancer, in press | Abstract
- Tolstov YL, Pastrana DV, Feng H, et al. 2009. "Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer in press | Abstract
- Shuda M, Feng H, Kwun HJ, Rosen ST, Gjoerup O, Moore PS, Chang Y. 2008. "T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus" Proc Natl Acad Sci USA. 105:16272-7. | Abstract
- Feng H, Shuda M, Chang Y, Moore PS. 2008. "Clonal integration of a polyomavirus in human Merkel cell carcinoma" Science 319:1096-100. | Abstract
- Feng H, Taylor JL, Benos PV, Newton R, Waddell K, Lucas SB, Chang Y, Moore PS. 2007. "Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma" J Virol. 81:11332-40. | Abstract
- Kwun HJ, da Silva SR, Shah IM, Blake N, Moore PS, Chang Y. 2007. "Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing" J Virol. 81:8225-35. | Abstract
- Moore PS, Chang Y, Jaffe HW. 2007. "Transmission of human herpesvirus 8 by blood transfusion" N Engl J Med. 356:88. | Abstract
- Laney AS, Peters JS, Manzi SM, Kingsley LA, Chang Y, Moore PS. 2006. "Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection" J Clin Microbiol. 44:3734-41. | Abstract
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