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Sidney M. Morris, Ph.D.
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Professor
W1255 BSTWR
200 Lothrop Street
Pittsburgh, Pennsylvania 15261
Phone: (412) 648-9338
Fax: (412) 624-1401
E-mail: smorris@pitt.edu
Lab Phone: (412) 648-9347
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Research
Research projects in my laboratory are directed toward elucidating the roles and regulation of the arginases in diseases such as asthma, sickle cell disease, hypertension, atherosclerosis, and renal fibrosis. As part of studies to determine the mechanism of action of the arginases in these diseases, we are evaluating the impact of arginase expression on synthesis of nitric oxide (NO), polyamines, and proline. We also are investigating the signal transduction pathways, DNA elements and transcription factors involved in regulating expression of the arginase genes in response to cytokines and other agents that play key roles in the disease processes. Our long-term goal is to identify new targets for therapeutic intervention in disease.
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Selected Publications
- Morris SM Jr. 2009. "Recent advances in arginine metabolism: roles and regulation of the arginases" Br J Pharmacol. 157:922-930. | Abstract
- Sasatomi K, Hiragata S, Miyazato M, Chancellor MB, Morris SM Jr, Yoshimura N. 2008. "Nitric oxide-mediated suppression of detrusor overactivity by arginase inhibitor in rats with chronic spinal cord injury" Urology 72:696-700. | Abstract
- Morris SM Jr. 2007. "Arginine metabolism: boundaries of our knowledge" J Nutr. 137:1602S-1609S. | Abstract
- Poljakovic M, Porter DW, Millecchia L, Kepka-Lenhart D, Beighley C, Wolfarth MG, Castranova V, Morris SM, Jr. 2007. "Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation" J Toxicol Environ Health, Part A 70: 118-127. | Abstract
- Erdely A, Kepka-Lenhart D, Clark M, Zeidler-Erdely P, Poljakovic M, Calhoun WJ, Morris SM, Jr. 2006. "Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages" Am J Physiol 290: 534-539. | Abstract
- Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sanchdev V, Hazen SL, Vichinsky EP, Morris SM, Jr.,Gladwin MT. 2005. "Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension and mortality in sickle cell disease" JAMA 294: 81-90. | Abstract
- Gray MJ, Poljakovic M, Kepka-Lenhart D, Morris SM, Jr. 2005. "Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta" Gene 353: 98-106. | Abstract
- Morris CR, Poljakovic M, Lavisha L, Machado L, Kuypers FA, Morris SM, Jr. 2004. "Decreased arginine bioavailability and increased serum arginase activity in asthma" Am J Resp Crit Care Med 170: 148-153. | Abstract
- Lee J, Ryu H, Ferrante RJ, Morris SM Jr, Ratan RR. 2003. "Translational control of inducible nitric oxide synthase expression by arginine can explain the “arginine paradox” Proc Natl Acad Sci USA 100: 4843-4848. | Abstract
- Morris SM, Jr. 2002. "Regulation of enzymes of the urea cycle and arginine metabolism" Ann Rev Nutr 22: 87-105. | Abstract
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