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Michael Tsang, Ph.D.
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Assistant Professor
5062 BST3
3501 Fifth Avenue
Pittsburgh, Pennsylvania 15213
Phone: (412) 648-3248
Fax: (412) 383-5918
E-mail: tsang@pitt.edu
Lab Phone: (412) 648-7928
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Research
Feedback Regulation of FGF Signaling: Fibroblast growth factors represent a large family of secreted molecules that serve critical functions during embryogenesis. Aberrant FGF signaling has been frequently associated with the development of cancers and congenital skeletal defects. The lab is interested in how FGF signaling levels are controlled to ensure proper signaling levels are achieved during embryogenesis. We have previously identified several molecules that function within the FGF pathway and have shown that they play an important role in limiting FGF signaling. We are presently studying the mechanism of how the FGF inhibitors, Sef and Mkp3 function in attenuating FGF signaling using zebrafish as a vertebrate model for development. A second aim is to define the role of FGFs signaling during development. The FGF pathway is important to maintain dorsal polarity and that disruption of this pathway results in ventralized zebrafish embryos. Our goal is understand how FGF signaling in the embryo is relayed into cell fate decisions.
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Selected Publications
- Molina G, Vogt A, Bakan A, Dai W, de Oliveira PQ, Znosko W, Smithgall TE, Bahar I, Lazo JS, Day BW, Tsang M. "Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages." Nat Chem Biol. 2009 Jul 5. [Epub ahead of print] | Abstract
- Kansara M., Tsang M., Kodjabachian L., Sims N., Trivett M., Ehrich M., Dobrovic A., Snell C., Slavin J., Choong PFM., Simmons PJ., Dawid IB., Thomas DM. 2009. "Epigenetic silencing of Wnt Inhibitory Factor 1 accelerates osteosarcomagenesis in vivo" Journal of Clinical Investigations doi:10.1172/JCI37175 | Abstract
- Shima T., Znosko, W., Tsang M. 2009. "The characterization of a zebrafish mid-hindbrain mutant, mid-hindbrain gone (mgo)" Developmental Dynamics 238: 899-907 | Abstract
- Vogt A., Cholewinski A., Shen X., Nelson S., Lazo J., Tsang M., Hukriede N. 2009. "Automated analysis of angiogenesis in zebrafish embryos by object-based image processing" Developmental Dynamics 238: 656-663 | Abstract
- Etheridge, SL., Ray S., Li, S., Hamblet, NS., Lijam, N., Tsang, M., Greer, J., Kardos, N., Wang, J., Sussman, DJ., Chen, P., Wynshaw-Boris, A. 2008. "Murine Dishevelled 3 functions in redundant pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea and Neural Tube Development" PLoS Genetics 4:e1000259 | Abstract
- Hong, S-K., Tsang, M., Dawid, IB. 2008. "The mych gene is involved in neural crest survival during zebrafish development" PLoS1 3:e2029 | Abstract
- Molina, G., Watkins, SC., Tsang, M. 2007. "Generation of FGF reporter transgenic zebrafish and their utility in chemical screens" BMC Developmental Biology 7:62 | Abstract
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Plisov, S*., Tsang, M*., Shi, G., Boyle, S., Kiyoshi, Y., Dunwoodie, S., Dawid, I., Shioda, T., Perantoni, A., de Caestecker, M. 2005. "CITED1 is a bi-functional transcriptional co-factor that regulates epithelial morphogenesis in the developing kidney" Journal of American Society of Nephrology 16:1632-44 | Abstract
- Tsang, M., Meagawa, S., Kiang, A., Habas, R., Weinberg, E., Dawid, I. 2004. "A role for Mkp3 in axial patterning of the zebrafish embryo" Development: 131: 2769-2779 | Abstract
- Tsang, M., Friesel, R., Kudoh, T., Dawid, I.B., 2002. "Identification of Sef: A novel modulator of FGF signaling" Nature Cell Biology 4:165-169 | Abstract
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