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Molecular Basis of Cancer

Several MMG research groups are investigating the molecular etiology of cancer induced by tumor viruses as well as the alterations in signaling pathways associated with oncogenic transformation. Specific projects are focused on the role of microRNAs in HPV-associated cervical cancer, the KSHV and MCV human tumor viruses, and protein-tyrosine kinases as molecular targets for cancer therapy.

Dr. SJ Gao
Shou-Jiang (SJ) Gao
Dr. Haitao Guo
Haitao Guo
Dr. Moore
Patrick S. Moore
Distinguished Professor
Dr. Kathy H.Y. Shair
Kathy H.Y. Shair
Assistant Professor
Dr. Smithgall
Thomas E. Smithgall
William S. McEllroy Professor and Chair
Gary Thomas

Associated Labs

Moore Lab

We study 1) Kaposi’s sarcoma-associated herpesvirus (KSHV), the viral cause of Kaposi’s sarcoma, 2)  Merkel  cell  polyomavirus  (MCV), the viral cause of Merkel cell carcinoma and 3) methods to search for undiscovered human tumor viruses.  Learn more>

Shair Lab

The Shair lab studies the molecular mechanisms of cancer induced by this latent virus with the purpose of defining how these mechanisms contribute to the oncogenic and metastatic properties of EBV-associated diseases. Learn more>

Smithgall Lab

This laboratory research is focused on non-receptor protein-tyrosine kinase structure, function, and inhibitor discovery. Interest lies specifically in the Src, Abl and Fes kinase families, which were originally discovered in the context of avian transforming retrovirus many years ago. Learn more>

Thomas Lab

Our research program focuses on signaling pathways that integrate membrane traffic with the regulation of homeostasis and the onset of disease. These studies were grounded by our identification of the proprotein convertase furin, which is the first member of a family of secretory pathway-localized endoproteases that catalyze the activation of bioactive proteins and peptide hormones. Learn more>

Associated Publications

Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer. 10: 878-889. | View Abstract
Fu, J; Qu, Z; Yan, P; Ishikawa, C; Aqeilan, R. I; Rabson, A. B; and Xiao, G. (2011) The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis. Blood. 117: 1652-1661. | View Abstract