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Flynn Lab

Principal Investigator

JoAnne L. Flynn, PhD
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5065 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15260

Research Description

Bone-marrow derived macrophages display heterogeneous phenotypesMy primary interest is in the interaction of pathogens with the host, with special emphasis on the immune mechanisms that protect against or exacerbate disease. Our focus is on Mycobacterium tuberculosis, the organism responsible for tuberculosis, which causes 2 million deaths per year worldwide. We are investigating the immune responses required for protection against tuberculosis, and the effect of these immune responses on both the host and the bacterium. We specifically study cytokine production, macrophage activation, and T cell subsets (CD4+ and CD8+ T cells) that are important in tuberculosis.

CD20... T cell- and B cell-mediated adaptive responses originate from cell-cell interactions that are initiated in lymph nodesFinally, we have a strong interest in the immune mechanisms responsible for maintaining a latent M. tuberculosis infection, and how deficiencies in the immune response can result in reactivation of disease. Our work is done in two model systems: mice and non-human primates. We have vaccine studies, drugs studies, and basic immunologic and pathogenesis studies ongoing. We also participate in projects involving mathematical modeling of the immune response to M. tuberculosis, and our plan is to incorporate nuclear imaging of live animals into our research.

Lab Members

Kara Kracinosky, Vet Tech  Joseph Zeppa, Postdoctoral Associate
Amy Fraser, Lab Manager Jake Borish, System Analyst
Alex White, Data Analyst
Jaime Tomko, Senior Research Specialist
Pauline Maiello, Data Analyst
Cassaundra Ameel, Research Technician
Lonnie Frye, Medical Imaging Technician
Sharie Ganchua, Graduate Student

Jennie Vorhauer, Research Specialist

Kush Patel, Research Specialist (Gideon)

Ryan Kelly, Research Technician

Janet Gleim, Research Technician

Mark Rodgers, RBL Research Tech Manager

 Skyler Pergalske, Vet Tech

Caylin Winchell, Post doctoral Associate

Erica Larson, Post doctoral Associate (Scanga Lab)

Jennifer Sakal, Vet Tech


Carolyn Mooney Bigbee -Senior Research Specialist
Charles A. Scanga -Research Associate Professor
Hannah Priyadarshini Gideon -Research Assistant Professor