Lori Emert-Sedlak, PhD

  • Research Associate Professor

Education & Training

  • PhD in Molecular Pharmacology, University of Pittsburgh School of Medicine, 2005
  • BS in Biochemistry and Molecular Biology, Pennsylvania State University, 1999

Research Interests

My research focuses on high-throughput drug discovery for inhibitors of the HIV-1 Nef and Vif accessory proteins. In addition to developing new assays that are compatible for screening large compound libraries, I work to define the biological relevance and the mechanism of the compounds that we discover. My project aims to develop the first drugs that target HIV-1 Nef.

Research Lab Affiliation

Smithgall Lab

Publications

Marcsisin SR, Narute PS, Emert-Sedlak LA, Kloczewiak M, Smithgall TE and Engen JR. 2011. On the solution conformation and dynamics of the HIV-1 Virion Infectivity Factor. J. Mol. Biol. 410: 1008-1022. |  View Abstract

Dikeakos JD, Atkins KM Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE and Thomas G. 2010. Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell. 21: 3279-3292. | View Abstract

Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K and Kahn ML. 2009. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci USA. 106: 21167-21672. | View Abstract

Emert-Sedlak L, Kodama T, Lerner EC, Dai W, Foster C, Day BW, Lazo JS and Smithgall TE. 2009. Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. ACS Chem Biol. 4: 939-947. | View Abstract

Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR and Smithgall TE. 2007. Allosteric Loss-of-function Mutations in HIV-1 Nef from a Long-Term Non-Progressor. J of Mol Biol. 374: 121-129. | View Abstract