Joseph C. Glorioso III, PhD


Dr. Glorioso


Fax: 412-624-1401

428 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219-3143


PhD in Microbiology, Louisiana State University

Research Summary

Dr. Glorioso has established a 35-year history of research related to the basic biology and genetics of herpes simplex virus. His contributions to the field include defining antiviral immune responses to infection, the genetics of viral pathogenesis and latency, and mechanisms of viral infection. Furthermore, he has been a pioneer in the design and application of HSV gene vectors for the treatment of nervous system diseases such as peripheral neuropathies, chronic pain, and brain tumors. He continues to be a worldwide leader in the HSV gene vector field through the creation of innovative gene vectors and the development of manufacturing methods for Phase I and Phase II human clinical trials for pain gene therapy. His enkephalin vector showed considerable promise in a Phase I human trial to treat cancer pain and phase II testing is underway. These trials were sponsored by Diamyd Medical AB in Stockholm. Dr. Glorioso is a Diamyd stockholder.
Dr. Glorioso’s most recent research has focused on (i) the design and application of HSV gene vectors for exploring the molecular events that occur in sensory afferents that are involved in the transition from acute to chronic pain, (ii) the development of retargeted oncolytic HSV vectors for specific infection and replication in human glioblastomas and applications to treatment of xenograft models of human brain human brain tumors, (iii) the creation of novel HSV vectors that cross the blood brain barrier by transcytosis followed targeted infection and gene expression in spiny neurons of the striatum; these vectors are being applied to treatment of animal models of Huntington’s disease and (iv) the use of HSV gene vectors for the creation of induced pluripotent stem (iPS) cells and the identification of transcriptional regulatory and signaling processes that participate in cellular reprogramming.


Research Lab Affiliation


Niedernhofer, L. J; Glorioso, J. C; and Robbins, P. D. (2011) Dedifferentiation rescues senescence of progeria cells but only while pluripotent. Stem Cell Res Ther. 2: 28. |  View Abstract

Dmitrieva, N; Yu, L; Viapiano, M; Cripe, T. P; Chiocca, E. A; Glorioso, J. C; and Kaur, B. (2011) Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. 17: 1362-1372. |  View Abstract

Fink, D. J; Wechuck, J; Mata, M; Glorioso, J. C; Goss, J; Krisky, D; and Wolfe, D. (2011) Gene therapy for pain: results of a phase I clinical trial. Ann Neurol. 70: 207-212. |  View Abstract

Goss, J. R; Cascio, M; Goins, W. F; Huang, S; Krisky, D. M; Clarke, R. J; Johnson, J. W; Yokoyama, H; Yoshimura, N; Gold, M. S; and Glorioso, J. C. (2011) HSV Delivery of a Ligand-regulated Endogenous Ion Channel Gene to Sensory Neurons Results in Pain Control Following Channel Activation. Mol Ther. 19: 500-506. |  View Abstract

Uchida, H; Chan, J; Goins, W. F; Grandi, P; Kumagai, I; Cohen, J. B; and Glorioso, J. C. (2010) A double mutation in glycoprotein gB compensates for ineffective gD-dependent initiation of herpes simplex virus type 1 infection. J Virol. 84: 12200-12209. |  View Abstract

Goss, J. R; Gold, M. S; and Glorioso, J. C. (2009) HSV vector-mediated modification of primary nociceptor afferents: an approach to inhibit chronic pain. Gene Ther. 16: 493-501. |  View Abstract

Wolfe, D; Craft, A. M; Cohen, J. B; and Glorioso, J. C. (2010) A herpes simplex virus vector system for expression of complex cellular cDNA libraries. J Virol. 84: 7360-7368. |  View Abstract