Shoucheng Du

  • Research Assistant Professor

Education & Training

  • Ph.D., Organic Chemistry, Technion-Israel Institute of Technology, Israel, 1998
  • M.S., Chemical Engineering, Tianjin University, China, 1989
  • B.S., Chemical Engineering, Hunan University, China, 1986

Research Interest Summary

Antimicrobial Drug Discovery and Vaccine Development

Research Interests

My interest lies in the structure-based drug discovery employing protein X-ray crystalography method. My current focuses are in the HIV-1 drug discovery and Acute myeloid leukemia (AML) drug discovery.

Publications

Du S, Alvarado JJ, Wales TE, Moroco JA, Engen JR, Smithgall TE. 2022. ATP-site inhibitors induce unique conformations of the cute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 11:1508-1517. doi: 10.1016/j.str.2022.08.008 | View abstract

Emert-Sedlak LA, Shi H, Tice CM, ChenL, Alvarado JJ, Shu ST, Du S, Thomas CE, Wrobel JE, Reitz AB, Smithgall TE. 2022. Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor. Viruses, 14, 9: 2025. doi:10.3390/v14092025 | View abstract

Emert-Sedlak LA, Moukha-Chafiq O, Shi H, Du S, Alvarado JJ, PAthak V, Tanner SG, Huter RN, Nebane M, ChenL, Ilina TV, Ishima R, Zhang S, Kuzmichev YV, Wonderlich ER, Schader SM, Augello-Szafran CE, Prak RG, Smithgall TE. 2022. Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation. ACS Infect Dis, 14, 8: 91-105. doi: 10.1021/acsinfecdis.1c00288 | View abstract

Aryal M, Lin D, Regan K, Du S, Shi H, Alvarado JJ, Ilina TV, Andreotti AH, Smithgall TE. 2022. The HIV-1 protein Nef activiates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction. Sci Signal, 15, 752: eabn8359. doi: 10.1126/scisignal.abn8359 | View abstract

Du S, Betts L, Yang R, Shi H, Concel J, Ahn J, Aiken C, Zhang P, and Yeh JI. 2011. Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding. J Mol Biol, 406, 3: 371-386. doi: 10.1016/j.jmb.2010.11.027 | View abstract