Ling Ding

  • Post Doc

Education & Training

  • PhD in Pathogenic Biology, Fudan University, 2019

Research Interest Summary

Multiple functions of CASTOR1 in inflammation, tumorigenesis, obesity, and aging.

Research Interests

Cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1) is a newly discovered arginine sensor, which negatively regulates mTORC1 activity. We have previously shown that CASTOR1 is tumor suppressive in KSHV-induced cellular transformation and breast cancer by regulating the mTORC1 activity and cell proliferation. However, the role of CASTOR1 in obesity, aging, inflammation, and other types of cancer remain unclear. We generated full body and conditional CASTOR1 knockout mice and using different models to investigate the function of CASTOR1 in obesity, senescence, inflammation, and cancer. We will provide abundance views of the mTOR pathway and its role in health and disease as well as aging. We further discuss pharmacological approaches to treat human pathologies linked to CASTOR1-mTOR deregulation.

Publications

Chen L, Ding L, Wang X, Huang Y, Gao S-J. 2023. Activation of glucocotocoid receptor signaling inhibits KSHV-induced inflamamtion and tumorigenesis. mBio, 15, 1: e0301123. doi: 10.1101/2023.11.10.566578 | View abstract 

Zhang FG, Meng W, Chen L, Ding L, Sun S, Wang X, hunag Y, Guo H, Gao S-J. 2023. Infectivity of pseudotyped SARS-CoV-2 variants of concern in different human cell types and inhibitory effects of recombinant spike protein and entry-related cellular factors. J-Med Virol, 95, 1: e28437. doi: 10.1002/jmv.28437 | View abstract

Zhang FG, Meng W, Chen L, Ding L, Feng J, Perez J, Ali A, Sun S, Liu Z, Huang Y, Guo H, Gao SJ. 2022. Neutralizing antibodies to SARS-CoV-2 variants of concern including Delta and Omicron in subjects receiving mRNA-1273, BNT162b2 and Ad26.COV2.S vaccines. J Med Virol, 94, 12: 5678-5690. doi: 10.1002/jmv.28032 | View abstract

Ding L, Zhu Q, Zhou F, Tan H, Xu W, Pan C, Zhu C, Wang Y, Zhang H, Fu W, Qian Z, Yuan Z, Xu H, Wei F, Cai Q. 2019. Indentification of viral SIM-SUMO2-interaction inhibitors for treating primary effucsion lymphoma. PLoS Pathog, 15, 12:e1008174. doi: 10.1371/journal.ppat.1008174 | View abstract

Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q. 2019. Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis. Cell Rep, 27, 5: 1633-1636. doi: 10.1016/j.celrep.2019.04.057 | View abstract

Click here for a full list of publications>